She first recorded with the saxophonist Kalaparusha Maurice McIntyre, and developed a rapport performing and recording with fellow AACM members including Muhal Richard Abrams, Lester Bowie, and Henry Threadgill. She has also performed with Archie Shepp, Charlie Haden’s Liberation Orchestra, James Blood Ulmer, Sonny Stitt, Anthony Braxton, Henry Threadgill, Rahsaan Roland Kirk and other well known artists.
Eleven albums have been recorded under her leadership featuring players like Jerome Harris, Reggie Nicholson, Pheeroan akLaff. Her recording career combines her gospel and blues inspirations with an improviser's freedom and includes classic albums like The Circle of Time, Amina Claudine Myers Salutes Bessie Smith, and solo piano and voice effort, Sama Rou (Songs From My Soul).
Relocating to New York City in 1976, Myer's further developed her work involving voice choirs, voice and instrumental ensemble, and a robust exploration of the pipe organ. Her compositions include large-scale works for orchestra and choir, and collaborations with writer Ntozake Shange and choreographer Dianne McIntyre.